TY - UNPB
T1 - Unveiling Parkinson's Disease-like Changes Triggered by Spaceflight
AU - Ali, Nilufar
AU - Beheshti, Afshin
AU - Hampikian, Greg
N1 - This is a preprint article. It offers immediate access but has not been peer reviewed.
PY - 2024
Y1 - 2024
N2 - A meta-analysis of spaceflight data from both mouse and human flights reveals a striking overlap with Parkinson's disease (PD). Parallels include: changes in gait, loss of dopamine, sustained changes in the basal ganglia, loss of tyrosine hydroxylase in the substantia nigra, and systemic mitochondrial dysfunction. We identified specific Parkinson's genes differentially expressed post-spaceflight. These evidences indicate that spaceflight stressor-induced changes in the brain may become permanent during deep space exploration, posing a risk of PD in astronauts.
AB - A meta-analysis of spaceflight data from both mouse and human flights reveals a striking overlap with Parkinson's disease (PD). Parallels include: changes in gait, loss of dopamine, sustained changes in the basal ganglia, loss of tyrosine hydroxylase in the substantia nigra, and systemic mitochondrial dysfunction. We identified specific Parkinson's genes differentially expressed post-spaceflight. These evidences indicate that spaceflight stressor-induced changes in the brain may become permanent during deep space exploration, posing a risk of PD in astronauts.
U2 - 10.48550/arXiv.2408.15021
DO - 10.48550/arXiv.2408.15021
M3 - Preprint
BT - Unveiling Parkinson's Disease-like Changes Triggered by Spaceflight
ER -
