Abstract
Smell of success: Reagent 1 provides the dual readouts of odor (ethanethiol) and fluorescence (derivative of 7-hydroxycoumarin) and can be used in down-selection assays based on smell and quantitative fluorescence assays of the samples that give a positive result. An important feature of 1 is the matched sensitivity of the two outputs. This reagent is designed for use in resource-limited settings and is demonstrated in assays that detect enzymes.
| Original language | English |
|---|---|
| Pages (from-to) | 11145-11148 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 51 |
| Issue number | 44 |
| DOIs | |
| State | Published - 29 Oct 2012 |
Keywords
- fluorescence spectroscopy
- hydrogen peroxide
- point-of-care
- sensors
- thiols
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